A 37-year-old immunocompetent female resident of Rio de Janeiro, Brazil, presented with a 2-month history of headache, without fever or any other symptoms. Results of serology for HIV and a venereal disease research laboratory test were both negative. Analyses of cerebrospinal fluid yielded normal findings. Brain magnetic resonance imaging (MRI) revealed a mass on the tentorium showing iso/hypointensity on T1- and T2-weighted images (Figure A and Figure B, respectively) with exuberant contrast enhancement (Figure C). Meningioma located in the tentorium was the main diagnosis. After surgical treatment, a histopathological diagnosis of histoplasmosis was made. Central nervous system (CNS) histoplasmosis commonly occurs in immunocompromised patients with disseminated infection1,2. The most common manifestation of CNS involvement is subacute or chronic meningitis1,2. Histoplasmosis mimicking a meningioma is exceptional and, in some cases, presents with the dural tail sign. This sign is seen on MRI as thickening of the dura mater, enhanced by venous contrast, which resembles a tail extending from a mass, and is generally related to meningiomas, which are the most common tumors of the meninges. In conclusion, histoplasmosis should be included in the differential diagnosis of CNS masses.