Home » Volumes » Volume 51 November/December 2018 » Diabetes insipidus secondary to tuberculous meningoencephalitis with hypothalamic involvement extending to the hypophysis: a case report

Diabetes insipidus secondary to tuberculous meningoencephalitis with hypothalamic involvement extending to the hypophysis: a case report

Monique Freire Santana1 2 Guilherme Augusto Pivoto João1 Marcus Vinicius Guimarães de Lacerda1 Luiz Carlos de Lima Ferreira1 3

1Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, Brasil. 2Departamento de Ensino e Pesquisa, Fundação Centro de Controle de Oncologia do Amazonas, Manaus, AM, Brasil. 3Departamento de Patologia e Medicina Legal, Universidade Federal do Amazonas, Manaus, AM, Brasil.

DOI: 10.1590/0037-8682-0455-2017

The involvement of Mycobacterium tuberculosis in the central nervous system (CNS) is a rare and devastating manifestation of tuberculosis


The involvement of Mycobacterium tuberculosis in the central nervous system (CNS) is an uncommon and devastating manifestation of tuberculosis. We report a case of disseminated tuberculosis presenting as meningoencephalitis, hypothalamic involvement with extension to the hypophysis, and secondary insipidus diabetes diagnosed at autopsy.

Keywords: Tuberculosis; Meningoencephalitis; Hypothalamus; Hypophysitis; Insipidus diabetes


The involvement of Mycobacterium tuberculosis in the central nervous system (CNS) is a rare and devastating manifestation of tuberculosis (TB). The frequency of CNS TB is approximately 1% of all cases of TB, with high mortality1. Clinical manifestations of CNS TB vary from meningitis, basilar arachnoiditis, tuberculoma, and encephalitis owing to devastating vasculopathy2. Tuberculous hypophysitis is a rare entity3, and secondary central insipidus diabetes due to sellar-suprasellar tuberculomas has been described elsewhere3. In 2015, the TB incidence rate in Brazil was 33.2 cases/100,000 inhabitants. The Amazonas State has the highest TB incidence rate, with 71.2 cases/100,000 inhabitants4. In 129 AIDS patients autopsied in the state of Amazonas, Souza et al. found that tuberculosis was a cause of death in 28% of cases5. The association between TB and drug abuse, especially crack cocaine, is a growing concern6. We present a case report of meningoencephalitis associated with hypothalamic involvement with extension to the hypophysis that resulted in diabetes insipidus, secondary to disseminated infection with M. tuberculosis, with a fatal outcome diagnosed at autopsy.


The patient was a 31-year-old man who came from Manaus (capital of the Amazonas State, Western Brazilian Amazon); he was an industrial worker, smoker, and user of illicit drugs (crack cocaine and marijuana) without previous contact with tuberculous patients. He sought medical care because of complaints of a headache, neck stiffness, behavioral changes, and otalgy on the left side; this had developed over eight days and was associated with nausea, postprandial vomiting, and mental confusion. The patient was admitted to the hospital. IV ceftriaxone and dexamethasone were promptly begun, and cerebral abscess of the temporal lobe was suspected. Forty-eight hours before hospital admission, a computed tomography (CT) scan was performed without alterations. Cerebrospinal fluid analysis disclosed mild lymphocytic pleocytosis with elevated protein levels. The patient developed a dry cough, otorrhea in the left ear, and periods of agitation; vancomycin was then added to the regimen. Given the clinical and laboratory suspicion of tuberculous meningoencephalitis, the COXCIP-4 scheme was started empirically. One day later, the patient was admitted to the intensive care unit with maintenance of the sensory level, respiratory distress with Kussmaul rhythm, seizures, hypotension, anisocoric pupils L > R without reaction to light, and diffuse respiratory snoring. The next day the patient developed refractory hemodynamic instability, polyuria with six mL/kg/hour urine output, and serious hypernatremia leading to death. The patient died within 20 days of the onset of symptoms. An autopsy was performed. The ectoscopy was unremarkable except for severe malnutrition. At the thoracic cavity overture, bilateral pleural-thoracic adherences were observed.

The lungs showed hemorrhagic areas at the base and micro-nodules with a millium appearance at the apical regions. On microscopy, the pulmonary parenchyma showed diffuse granulomas, some with caseous necrosis. The Ziehl-Neelsen stain showed a few acid-fast bacilli (AFB). In the abdominal cavity, the diaphragmatic surface had several white-yellowish micro-nodules, and on microscopic examination, they are represented by well-defined granulomas. The liver, spleen, bone marrow, kidneys, and adrenal glands were not altered in the macroscopic examination; however, all of these organs showed granulomatous involvement on microscopy. CNS examination showed diffuse edema with intense exudate in the optic chiasma region covering the brain stem, and many dots of hemorrhages at the cerebral surface. The basal meninges demonstrated thick, gelatinous subarachnoid exudate that filled the basal cisterns and diffuse leptomeningitis (Figure 1). Coronal sections of the cerebral hemispheres showed a necrotic lesion involving the left basal ganglia and the adjacent part of the claustrum, the hypothalamic region bilaterally, which was more accentuated to the left, and the inferior part of the right basal ganglia, extending to the junction of the claustrum with the superior temporal gyrus (Figure 2), granular exudate in the lateral ventricles, and hydrocephalus. Granulomatous ventriculitis with a few AFB on Ziehl-Neelsen stain was seen, as well as several fibrin thrombi with vasculitis, fibrinoid necrosis of the vessel walls, and an intense perivascular inflammatory infiltrate consisting of neutrophils, lymphocytes, and histiocytes (Figure 3). The necrotic lesions in the basal ganglia showed vascular neoformation and eosinophilic neurons with pyknotic nuclei, which are characteristic of cerebral infarction. The subarachnoid space was filled by an intense inflammatory infiltrate with neutrophils, lymphocytes, and histiocytes, with infiltration of the adjacent brain parenchyma. The hypothalamus and pituitary gland showed diffuse necrosis on gross pathology, with partial destruction of the pituitary parenchyma by an intense inflammatory infiltrate of lymphocytes and epithelioid cells (Figure 4). A Grocott stain was performed in all tissues with granulomatous involvement, which were negative for fungal structures.

FIGURE 1: Gross pathology of brain: Thick, gelatinous subarachnoid exudate that fills the basal cisterns. 

FIGURE 2: Cross-sections of brain: Extensive necrotic lesion involving the left basal ganglia and the claustrum, hypothalamus (circle), and the inferior part of the right basal ganglia. 

FIGURE 3: Tuberculous cerebral vasculitis: Vasculitis with fibrinoid necrosis (Hematoxylin & Eosin, 200x). 

FIGURE 4: Tuberculous Hypophysitis: Parenchymal destruction by intense inflammatory infiltrated with lymphocytes and epithelioid cells (Hematoxylin & Eosin, 400x). 


CNS TB is uncommon and frequently fatal1. Hydrocephalus, vasculitis-causing infarction, and cranial neuropathies have been described as complications of tuberculous meningitis (TBM). Other manifestations are pachymeningitis, granulomatous basal meningitis, parenchymal tuberculosis (included parenchymal tuberculomas, tuberculous abscesses, miliary tuberculomas, focal tuberculous cerebritis, and encephalopathy), tuberculoma en plaque, tuberculous hypophysitis, involvement of the calvarium and the base of skull, orbital tuberculosis, tuberculous otitis media, temporal bone tuberculosis, and spinal tuberculosis7. Tuberculous ventriculitis is an uncommon disease, with only a few cases reported8. Small superficial tuberculomas are quite common in tuberculous leptomeningitis; however, large tuberculomas are rare in patients with leptomeningitis, whereas infarction may be present in 25%. In these patients, predictors of a poor outcome are old age, high TBM grading, presence of infarction, and hydrocephalus9. In the present case, no tuberculoma was found; however, several infarction areas were present with extensive destruction of the parenchyma, which is associated with hydrocephalus.

In comparison to patients with noninflammatory ischemic stroke (IS), the most frequent infarction areas in TBM were described in the TB zone, which is supplied by the medial striate and thalamoperforating arteries. In patients with IS, the most commonly affected area was supplied by the lateral striate, anterior choroidal, and thalamogeniculate arteries; however, the opposite was observed in patients with TBM10.

TB cerebral vasculitis can be included in the differential diagnosis in complications of any case of tuberculous meningitis. In a 41-year-old woman with TBM, tuberculous vasculitis was seen on day 30, with perforated infarction occurring around Willis’ circle and debris located at the base of the skull, without evidence of the narrowing of an artery inside the brain. With supportive care and an increased dosage of prednisolone, her condition gradually improved without significant neurological disorder11. In this case, the patient presented with several cerebral infarctions as a complication of extensive vasculitis, probably leading to the poor prognosis. Pituitary TB is very rare. The most common presentation is chronic granulomatous inflammation associated with hypopituitarism12. The present patient died because of tuberculous meningoencephalitis, with extensive cerebral infarctions secondary to vasculitis and hypothalamic/pituitary involvement associated with diabetes insipidus. This case draws attention to the broad spectrum of involvement by M. tuberculosis in the CNS. In geographic areas with a high prevalence of tuberculosis, empirical treatment must be performed early because of the commonly fatal outcome.


The authors thank the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado and the Post-Graduate Program in Tropical Medicine, from Universidade do Estado do Amazonas, for the encouragement and support of scientific publications.


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1Ethical considerations: The autopsy was performed after relatives’ formal consent.

Received: December 10, 2017; Accepted: July 18, 2018

Corresponding author: Monique Freire Santana. e-mail:monique.freire20@gmail.com

Conflict of Interest: The authors declare that there is no conflict of interest.