A 13-year-old girl presented to the emergency department with fever for six days and hyporexia, abdominal pain, and headache. Associated exanthematous lesions on the left upper arm and both lower limbs had appeared three days after fever onset. On physical examination, we noticed numerous purpuric and flattened bullous lesions on the upper arms, resembling extensive burns (Figure 1A-1C). She had no other complaints; no history of joint swelling, myalgia, vomiting, or conjunctivitis; and no prior drug history. Blood count, liver, and renal function test results and abdominal ultrasound were normal. Erythrocyte sedimentation rate (55 mm) and C-reactive protein (12 mg/L) levels exceeded the normal range. An immunoglobulin M enzyme-linked immunosorbent assay revealed Chikungunya virus positivity. She received symptomatic supportive treatment, adequate hydration, and rest. Antibiotics were deemed unnecessary. After approximately three days, she was asymptomatic, and the lesions regressed with skin detachment (Figure 2).
Chikungunya fever caused by the Chikungunya virus is usually self-limiting. An early-stage rash commonly develops during the first two days of fever, followed by a maculopapular rash with centrifugal distribution. Vesiculobullous lesions in children following Chikungunya fever have been reported previously1. Hyperpigmentation, multiple aphthous-like ulcers, ecchymosis, subungual hemorrhage, and generalized erythema may also occur2. Differentials, such as autoimmune disorders, drug reactions, and viral and bacterial infections, should be excluded3. This case highlights the importance of considering Chikungunya fever as a differential diagnosis while evaluating vesiculobullous lesions in children in new endemic areas where physicians are not fully familiar with this emergent disease.