Pedro Raso; Paulo Marcos Z. Coelho; Nivaldo H. Toppa; Rômulo T. Mello
ABSTRACT
In this study, which was undertaken in relation to the histopathologic behavior of two different strains (LE-Belo Horizonte, MG and SJ – São José dos Campos, SP) in infections and reinfections (homologous or heterologous) with Schistosoma mansoni, the authors confirmed a more accentuated pathogenicity of the SJ strain. All the reinfections showed the presence of typical granulomas of the acute phase, when performed either with the same strain (homologous) or with a different strain (heterologous) of the parasite of the primo infection. The possible mechanisms responsible for reactivation of the immunopathologic response in reinfections are discussed.
Keywords: Granuloma. Granulomatous reaction. Schistosoma mansoni. Geographical strains.
RESUMO
No presente estudo, verificou-se o comportamento histopatológico das infecções e reinfecções, homólogas ou heterólogas, das cepas LE (Belo Horizonte, MG) e SJ (São José dos Campos, SP) de Schistosoma mansoni. Confirmou-se uma maior patogenicidade da cepa SJ de S. mansoni. As reinfecções, independentemente de terem sido feitas com a mesma cepa (homóloga) ou cepa diferente da primo infecção (heteróloga) do parasito, mostraram a presença de granulomas típicos da fase aguda. São discutidos os possíveis mecanismos responsáveis pela reagudização da resposta imunopatológica nas reinfecções.
Palavras-chave: Granuloma. Reação granulomatosa. Schistosoma mansoni. Cepas geográficas.
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Adress to correspondence:
Prof. Paulo Marcos Z. Coelho.
GIDE/ICB/UFMG,
Caixa Postal 486,
30161-970
Belo Horizonte, MG, Brasil.
Recebido para publicação em 30/03/94.
Universidade Federal de Ouro Preto, Ouro Preto, MG e Departamentos de Parasitologia do Instituto de Ciências Biológicas, de Anatomia Patológica da Faculdade de Medicina e de Análises Clínicas e Toxicológicas da Faculdade de Farmácia, Universidade Federal de Minas Gerais, MG, Brasil.
Financial support from CNPq, FAPEMIG, FINEP, PRPq, Brazil and WHO, Switzerland.
