Home » Volumes » Volume 26 July/September 1993 » Quimioprofilaxia da malária com mefloquina na amazônia brasileira

Quimioprofilaxia da malária com mefloquina na amazônia brasileira

João Barberino Santos; Aluízio Prata; Eduardo Wanssa

DOI: 10.1590/S0037-86821993000300005


RESUMO

Em estudo randômico dupb-cego, 122 voluntários morando em área endêmica de malária na Região Amazônica (Estado de Rondônia) foram divididos em quatro grupos para estudo da supressão malárica. O grupo 1 recebeu 500mg de mefloquina a cada quatro semanas; o grupo II 250mg de mefloquina a cada duas semanas; o grupo III um comprimido de Fansidar (500mg de sulfadoxina + 25mg de pirimetamina) por semana e o grupo IV, recebeu apenas placebo. Um ataque agudo de malária ocorreu em um indivíduo do grupo 1, em dois indivíduos do grupo II e em seis indivíduos dos grupos III e IV. A proteção verificada nos grupos em uso de mefloquina foi significantemente superior comparada ao grupo placebo. A mefloquina, em ambas as dosagens usadas, mostrou-se efetiva na supressão malárica em uma área onde o Plasmodium falciparumplurirresistente é altamente prevalente.

Palavras-chave: Malária. Mefloquina. Quimioprofilaxia.


ABSTRACT

In a randomised double blind study 122 volunteers living in an endemic malarious area in Amazonian Rondonia State were divided into 4 groups to study malaria supression. The first group received 500mg of mefloquine every month, group II 250mg every two weeks, group III a tablet of Fansidar (500mg sulphadoxine + 25mg pyrimethamine) a week and group IVplacebo. Acute attacks of malaria occured in one individual in group I, 2 subject in group II, and 6 individuals in groups 111 e IV. Protection with mefloquine was significant compared with the placebo group. Both treatment regimens with mefloquine were effective supressants in an area of high prevalence of drug multiresistant Plasmodium falciparum transmission.

Keywords: Malaria. Mefloquine. Chemoprophylaxis.


 

 

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 Endereço para correspondência:
Dr. João Barberino Santos.
Centro de Pesquisa e Tratamento de Malária do Vale do Guaporé.
Av. Limoeiro s/n.
78971-000
Costa Marques, RO.

 

 

Recebido para publicação em 15/05/91.

 

 

Núcleo de Medicina Tropical e Nutrição da Universidade de Brasília, Brasília, DF.