Selir M. Straliotto; Benjamin Roitman; João B. Lima; Gilberto B. Fischer; Marilda M. Siqueira
ABSTRACT
The grouping characteristics of 29 respiratory syncitial virus (RSV) present in nasopharyngeal cells collectedfrom hospitalized children with bronchiolitis during the 1990RSVseason in Porto Alegre, RS, were analysed. Twenty-two were grouped as belonging to group A and 7 to group B. Cyanosis, oxigen therapy, cough, lenght of hospitalization and atelectasis were observed to be more frequently found within group B infected children. Other clinical signs and symptoms were similarly found in both groups.
Keywords: Respiratory syncytial virus. Bronchiolitis. RSV groups A and B.
RESUMO
Estudos recentes de amostras do vírus respiratório sincicial (VRS) usando anticorpos monoclonais distiguiram duas variantes antigênicas, designadas como grupos A e B. Estes grupos foram estudados em 29 secreções de nasofaringe positivas para o VRS, provenientes de crianças hospitalizadas com bronquiolite durante surto de virose por VRS, em Porto Alegre, em 1990. Destas, 22 foram grupadas como pertencentes ao grupo A e 7 ao grupo B. Alguns achados clínicos como cianose, tosse, uso de oxigênio e dias de hospitalização foram mais freqüentemente observados em crianças infectadas coin o grupo B do VRS. Outros sinais e sintomas clínicos foram similarmente encontrados nos 2 grupos.
Palavras-chave: Vírus respiratório sincicial. Bronquiolite. Grupos A e B de VRS.
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REFERENCES
1. Akerlind B, Norrby E. Occurrence of respiratory syncytial virus subtypes A and B strains in Sweden. Journal Medical Virology 19:241-247, 1986. [ Links ]
2. Anderson LJ, Hierholzer JC, Tsou C, Hendry RM, Fernie BF, Stone Y, McIntosh K. Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodies. Journal of Infectious Diseases 151:626-633, 1985. [ Links ]
3. Gardner PS, McQuillin J. Rapid virus diagnosis. Application of immunofluorescence. 2nd edition, London, Butterworths, 1980. [ Links ]
4. Hall CB, Walsh EE, Schnabel KN, Long CE, McConnochie KM, Hildreth SW, Anderson LJ. Occurrence of groups A and B of RSV over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. Journal of Infectious Diseases 162:1283- 1290, 1990. [ Links ]
5. Hendry RM, Pierik LT, McIntosh K. Prevalence of RSV subgroups over six consecutive outbreaks: 1981-1987. Journal Infectious Diseases 160:185- 190, 1989. [ Links ]
6. Jonhson Jr PR, Olmsted RA, Prince GA, Murphy BR, Ailing DW, Walsh EE, Collins PL. Antigenic relatedness between glycoproteins of human RSV subgroups A and B: evaluation of the contributions of F and G glycoproteins to immunity. Journal of Virology 61:3163-3166, 1987. [ Links ]
7. Kim HW, Arrobio JW, Brandt GD, Jeffries BC, Pyles G, Reid JL, Chanock RM, Parrot RH. Epidemiology of respiratory syncytial virus infection in Washington, DC. I importance of the virus in different tract disease syndromes and temporal distribution of infection. American Journal of Epidemiology 95:216-225, 1973. [ Links ]
8. McConnochie KM, Hall CB, Walsh EE, Roghmann KJ. Variation in severity of respiratory syncytial virus infection with subtype. Journal of Pediatrics 117:52-62, 1990. [ Links ]
9. Mufson MA, Belshe RB, Orvell C, Norrby E. RSV epidemics: variable dominance of subgroups A and B strains among children, 1981-1986. Journal Infectious Diseases 157:143-148, 1988. [ Links ]
10. Mufson MA, Orvell C, Rafnar B, Norrby E. Two distinct subtypes of human respiratory syncytial virus. Journal of General Virology 66:2111-2114, 1985. [ Links ]
11. Mulholland EK, Olinsky A, Shann FA. Clinical findings and severity of acute bronchiolitis. Lancet 335:1259-1261, 1990. [ Links ]
12. Pan Americam Health Organization. Acute respiratory infections in children. Washington, DC: Pan American Health Organization, 1982. [ Links ]
13. Russi JC, Chiparelli H, Montano A, Etorena P, Hortal M. Respiratory syncytial virus subgroups and pneumonia in children. Lancet (letter): 1039- 1040, 1989. [ Links ]
14. Russi JC, Delfraro A, Arbiza JR, Chiparelli H, Orwell C, Grandien M, Hortal M. Antigenic characterization of respiratory syncytial virus associated with acute respiratory infections in Uruguayan children from 1985 to 1987. Journal of Clinical Microbiology 27:1464-1466, 1989. [ Links ]
15. Salomon HE, Avila MM, Cerqueiro MC, Orwell C, Weissenbacher M. Clinical and epidemiologic aspects of respiratory syncytial virus .antigenic variants in Argentinian children. Journal of Infectious Diseases 163:1167, 1991. [ Links ]
16. Siqueira MM, Ferreira V, Nascimento JP. RS virus diagnosis: comparison of isolation, immunofluorescence and enzyme immunoassay. Memórias do Instituto Oswaldo Cruz 81:225-232, 1986. [ Links ]
17. Siqueira MM, Nascimento JP. Respiratory syncytial virus: occurrence of subgroups A and B strains in Rio de Janeiro. Memórias do Instituto Oswaldo Cruz 85:483-484, 1990. [ Links ]
18. Siqueira MM, Nascimento JP, Anderson LJ. Antigenic characterization of RSV group A and B isolates in Rio de Janeiro, Brazil. Journal of Clinical Microbiology 29:557-559, 1991. [ Links ]
19. Taylor CE, Morrow S, Scott M, Young B, Toms GL. Comparative virulence of respiratory syncytial virus subgroups A and B. Lancet 1:777-778, 1989. [ Links ]
20. Tsutsumi H; OnumaM, Suga K, Honjo T, Chiba Y, Chiba S, Ogra PL. Occurrence of RSV subgroup A and B strains in Japan, 1980 to 1987. Journal of Clinical Microbiology 26:1171-1174, 1988. [ Links ]
21. Waris M. Pattern of respiratory syncytial virus epidemics in Finland: two-years cicles with alternating prevalence of groups A and B. Journal of Infectious Diseases 163:464-469, 1991. [ Links ]
Adress to correspondence:
Dra. Marilda M. Siqueira.
Depto. de Virologia/ FIOCRUZ.
CP: 926,
21045-900
Rio de Janeiro, RJ, Brasil
Tel: (021) 598-4360
Fax: (021) 270-6397.
Recebido para publicação em 29/09/92.
Instituto de Pesquisas Biológicas, Hospital de Clínicas de Porto Alegre, Hospital das Crianças Santo Antônio, Porto Alegre, RS e Departamento de Virologia, Fundação Oswaldo Cruz, Rio de Janeiro, RJ.
