Maria Imaculada Muniz-Junqueira; José Tavares-Neto; Meire Ataide; Aluizio Prata; Carlos Eduardo Tosta
ABSTRACT
It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests using recall antigens in a group of 22 patients with hepatosplenic schistosomiasis, one year after treatment with oxamniquine and compared with a group of untreated hepatosplenic patients. Only 27% of treated patients presented complete anergy to all tested antigens, in marked contrast to 80% unresponsiveness showed by hepatosplenic patients without treatment. Although most of the treated individuals showed some response to the tested antigens, in some individuals this unresponsiveness still persisted after treatment. Anergy was not found in any normal individual of the control group. It was concluded that Schistosoma mansoni infected patients may recover their normal immune responsiveness after the elimination of the worm by treatment
Keywords: Immunodepression. Schistosomiasis. Oxamniquine.
RESUMO
Tem sido observado que infecção por Schistosoma mansoni pode causar imunodepressão celular. Neste trabalho foi avaliado se a imunodepressão associada à esquistossomose pode ser revertida pelo tratamento especifico. A resposta imune celular foi determinada através de testes cutâneos de hipersensibilidade retardada em 22 pacientes com a forma hepatoesplênica da esquistossomose um ano após tratamento com oxamniquine e comparado com aquela observada em um grupo de pacientes hepatoesplênicos não tratados. Somente 27% destes pacientes apresentaram alergia a todos os antígenos testados, em contraste com 80% de indivíduos anêrgicos observados entre aqueles não tratados. Embora a maioria dos indivíduos tratados tenha mostrado algum grau de resposta aos antígenos testados, alguns indivíduos permaneceram anérgicos após o tratamento específico. Anergia a todos os antígenos aplicados não foi observada em nenhum dos indivíduos normais. Nossos dados indicam que pacientes esquistossomóticos podem recuperar sua reatividade imune após a eliminação do verme pelo tratamento específico.
Palavras-chave: Imunodepressão. Esquistossomose. Oxamniquine.
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Adress to correspondence:
Dra Maria Imaculada Muniz- Junqueira
Laboratório de Imunologia
Departamento de Patologia/FCS/UnB.
70910
Brasília, DF, Brasil.
Recebido para publicação em 22/01/91.
Núcleo de Medicina Tropical e Nutrição e Laboratório de Imunologia Celular, Faculdade de Ciências da Saúde, Universidade de Brasilia, Brasília, DF. Faculdade, de Medicina do Triângulo Mineiro, Uberaba, MG.
Grants: CNPq (Proc. 40.1041/PIDE VI and 40.1868/87).
