João Barberino Santos; Aluízio Prata
RESUMO
Foi avaliada a resposta terapêutica em 75 doentes com malária pelo P. falciparum, em Porto Velho – Rondônia, tratados com mefloquina nas doses de 1250, 1000 e 750 mg. Não houve diferença significante nos resultados obtidos nos três grupos. Até o terceiro dia de tratamento, a febre desapareceu em 76,0% dos casos. A parasitemia negativou-se em 68,0% dos pacientes nos 3 primeiros dias após o inicio do tratamento, em 24,0% no quarto dia e em 5,3% no quinto.Havia um doente positivo no sexto dia e outro no sétimo. Nenhum paciente apresentou trofozoito no período de seguimento de 7 a 28 dias. Não houve modificações do quadro hematológico, exceto por um incremento da taxa de reticulócitos em 76,0%. As alterações bioquímicas registradas no seguimento dos doentes constaram de elevação da desidrogenase lática (28,0%) e, dafosfatase alcalina (41,3%). As reações colaterais foram discretas e infreqüentes; em 72,0% dos tratados não se constatou nenhum efeito secundário. Não se verificou nenhum caso de recidiva. A mefloquina revelou-se eficaz e bem tolerada no tratamento da malária no Estado de Rondônia.
Palavras-chave: Malária. Mefloquina. Tratamento.
ABSTRACT
Mefloquine was evaluated for the treatment of falciparum malaria in 75 patients in Porto Velho, Rondonia. Each patient was randomly assigned to one of three treatment groups and treated under a double blind protocol with a total dose of750,1000 or 1250 mg of mefloquine per person. There were no significant differences among the groups. By the thirdy day of treatment 76% of the patients were without fever and 68% were without parasites. The hemograms were normal except for an increase in the number of reticulocytes in 76% of the patients. The concentration of lactic dehydrogenase in serum was elevated in 28% of the patients and the concentration of alkaline phosphatase was elevated in 41 %. Mild side effects were encountered in 18% of the patients. None of the patients suffered a relapse of malaria. It is concluded that mefloquine is practical, efficacious and safe for the treatment of falciparum malaria.
Keywords: Malaria. Mefloquine. Treatment.
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Recebido para publicação em 8/7/88.
Núcleo de Medicina Tropical e Nutrição da Universidade de Brasília 70910 – Brasília-DF
