Reinaldo Martinelli; Rosemarie Lorenço; Heonir Rocha
ABSTRACT
Abnormalities of renal function have been demonstrated inpatients with visceral leishmaniasis; although there was a trend toward normalization following antiparasitic therapy, some abnormalities persisted. With thepurpose of studying the long- term clinical course of renal involvement in visceral leishmaniasis, 32 patients with a diagnosis of this parasitic disease were evaluated in the endemic area and at least 6 months after the clinical cure of the disease and compared with a control group of 28 individuals. No patient had a history or clinical findings suggestive of renal disease and all were normotensive. Laboratory evaluation was normal in all except 3 patients with abnormal urinalysis. Mild proteinuria and microscopic hematuria were seen in a single urinalysis in one patient (although three other urinalysis were normal), and leucocyturia in two female patients. It was concluded that the renal involvement in visceral leishmaniasis is mild and transient, with normal renal function observed on long-term follow-up after cure of the parasitic infection.
Keywords: Visceral leishmaniasis. Nephropathy. Reversibility. Clinical Course. Parasitic disease.
RESUMO
Anormalidades das funções renais têm sido demonstradas em pacientes portadores de leishmaniose visceral; embora haja tendência à normalização logo após o tratamento antiparasitário, algumas dessas anormalidades persistem. Com o propósito de estudar o curso clínico a longo prazo do envolvimento renal na leishmaniose visceral, 32 pacientes foram estudados na área endêmica, pelo menos 6 meses após a cura clínica da doença, e comparado a um grupo-controle de 28 indivíduos. Em nenhum paciente se documentou história ou dados clínicos sugestivos de doença renal. A avaliação laboratorial foi normal em todos os pacientes, exceto 3 com sumários de urina anormais em um, proteinúria leve e hematúria microscópica num único sumário de urina (três outros foram normais) e leucocitúria em dois outros pacientes. Concluiu-se que na leishmaniose visceral o envolvimento renal é discreto e transitório, havendo desaparecimento das alterações sugestivas de disfunção após a cura da doença parasitária.
Palavras-chave: Leishmaniose visceral. Nefropatia. Reversibilidade. Curso Clínico.
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Adress to correspondence:
Dr. Reinaldo Martinelli, M. D.
Hospital Prof. Edgard Santos
Laboratório 1117
Nefrologia
Rua João das Botas, s/n – Canela
40000
Salvador – Bahia – Brasil.
Recebido para publicação em 26/6/1986.
Department of Medicine, Federal University of Bahia, Salvador – Bahia – Brazil.
This work was supported by grants n° 40.3684/82 (Conselho Nacional de Desenvolvimento Científico e Tecnológico) and AI-16282 of National Institute of Health.
