Tatsuto KimachiI; Joel P. R. VeigaII; Euclydes C. Lima-FilhoIII
IDepartment of Internai Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto IIDepartment of Specialized Medicine, Faculty of Health Sciences, University of Brasilia, Brasília IIIDepartment of Genetics and Mathematics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ri beirão Preto
ABSTRACT
The osmotic threshold for vasopressin release was studied in normal patients (n = 7) and in patients with the chronic form of Chagas’disease (n = 11). Positive correlation between osmotic threshold and plasma cortisol concentration was obtained for the Controls (y1 = 273,30 + 0,75xi; r = 0,78;P < 0,05), suggesting a modulating effect of cortisol on vasopressin release. The lack of correlation between the two parameters for the chronic chagasic patients was interpreted, on the basis of the general denervation associated with Chagas ‘ disease, to be the result of neuronal destruction in hypothalamic and/or extrahypothalamic centers related to the secretory control of vasopressin.
Keywords: Plasma Cortisol Concentration. Osmotic Threshold. Vasopressin Release. Chronic Chagas’ Disease.
RESUMO
O limiar osmótico para liberação da vaso- pressina foi estudado em pacientes normais (n = 7) e em pacientes com a forma crônica da moléstia de Chagas (n = 11). Verificou-se a existência de uma correlação positiva entre o limiar osmótico e a concentração plasmática do cortisol endógeno para os controles (y1 = 273,30 + 0,75 xi; r = 0,78, p < 0,05), sugerindo um efeito modulador do cortisol na liberação da vasopressina. A falta de correlação entre os dois parâmetros, para os pacientes chagásicos crônicos, interpretou-se, baseando-se na desnervação geral associada com a doença de Chagas, como sendo o resultado da destruição neuronal em centros hipotalâmicos ejou extra-hipotalâmicos relacionados com o controle secretário da vosopressina.
Palavras-chave: Concentração plasmática de cortisol. Limiar osmótico. Liberação de vasopressina. Doença de Chagas crônica.
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Adress to correspondence:
JPR Veiga
Department of Specialized Medicine
Faculty of Health Sciences
University of Bra silia.
Brasília.
CEP 70.910.
Recebido para publicação em 15/4/1983.
1 Research carried out in the Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, with the support of FAPESP (Grant 76/1177) and FINEP (Grant 13/39/79/349/00/00).
