Home » Volumes » Volume 19 January/March 1986 » Schistosoma mansoni: immunodepression of hepatic schistosome granuloma formation in mice infected by Trypanosoma cruzi*

Schistosoma mansoni: immunodepression of hepatic schistosome granuloma formation in mice infected by Trypanosoma cruzi*

O. GenaroI; Z. BrenerII; P.M.Z. CoelhoIII

IDepartamento de Patologia Tropical/INPA, Manaus IICentro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte IIIDepartamento de Parasitologia, ICB/UFMG, Belo Horizonte

DOI: 10.1590/S0037-86821986000100008


ABSTRACT

Infection by Trypanosoma cruzi in mice depresses hepatic granuloma formation around Schistosoma mansoni eggs. This immunodepressive effect occurred in mice with Chagas’ disease at the acute and/or chronic phases, granulomas being signijicantly smaller than those in Controls. Data suggest that Chagas ‘ disease depresses the delayed hypersensitivity immune response directly.

Keywords: Schistosoma mansoni. Immunodepression. Granuloma. Trypanosoma cruzi.


RESUMO

A infecção de camundongos pelo Trypanosoma cruzi inibe a formação do granuloma hepático esquistossomótico. Este efeito imunodepressor ocorreu em camundongos com a fase aguda ou crônica da doença de Chagas, sendo os granulomas significativamente menores que nos animais controles. Os dados sugerem que a doença de Chagas deprime diretamente a imunidade celular.

Palavras-chave: Schistosoma mansoni. Imunodepressão. Granuloma. Trypanosoma cruzi.


 

 

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REFERENCES

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 Endereço para correspondência:
Prof? Paulo Marcos Z. Coelho
Departamento de Parasitologia
ICB/UFMG
Caixa Postal 2486
30000 Belo
Horizonte, MG.

 

 

Recebido para publicação em 26/6/1985.

 

 

* This study was supported by CNPq and FINEP, Brazil.