Home » Volumes » Volume 17 April/June 1984 » The association of Schistosoma mansoni infection with hepatocellular carcinoma*

The association of Schistosoma mansoni infection with hepatocellular carcinoma*

Fausto Edmundo Lima Pereira; Carlos Sandoval Gonçalves

DOI: 10.1590/S0037-86821984000200005


ABSTRACT

The association of Schistosoma mansoni infection with hepatocellular carcinoma (HCC) was studied in Espirito Santo State, Brazil. Schistosoma infection was diagnosed by stool examinations or by histological finding at autopsy. HCC was diagnosed by biopsy, laparoscopy and biopsy or at autopsy. Among 45 cases of HCC six had Schistosoma mansoni infection (13.04%). The occurrence of Schistosoma infection among HCC HBs Ag positive or negative was similar (13.3 3% and 13.63% respectively). The chi squared comparison showed no significant differences between the frequency of schistosomiasis in patients with HCC and the frequency of Schistosoma infection among people living in the Espirito Santo State (5.9% among children of elementary school from all the counties of the State and 6.7% in people that attended medical care in Vitoria, the capital of the State). Therefore, the authors believe that the association of schistosomiasis mansoni with HCC may be casual, specially in areas where the Schistosoma mansoni infection is frequent.

Keywords: Schistosomiasis mansoni. Hepatocellular carcinoma.


RESUMO

Foi estudada a associação de infecção pelo Schistosoma mansoni em pacientes portadores de carcinoma hepatocelular (CHC) diagnosticados no Espírito Santo. O diagnóstico de esquistossomosefoi feito pelo exame parasitológico das fezes ou pelos achados histológicos à necrópsia. O diagnóstico de CHC foi feito por laparoscopia e biópsia, somente biópsia ou por necrópsia. Entre 45 casos de CHC, seis apresentavam infecção pelo S. mansoni(13,04%). A ocorrência de infecção esquistossomótica nos CHC HBsAg positivos ou negativos foi semelhante (13,33 e 13,63% respectivamente). A comparação pelo método do qui quadrado não mostrou diferença significativa entre a freqüência de infeccção esquistossomótica nos pacientes com CHC e a freqüência de esquistossomose na população que vive no E. Santo (5,97% entre crianças do curso primário de todas as regiões do Estado e 6,75% entre a população que procura recursos médicos em Vitória, a capital do Estado). Desta forma os autores acreditam que a associação de infecção esquistossomótica e CHC deve ser casual, especialmente nas áreas onde a esquistossomose é freqüente.

Palavras-chave: Esquistossomose mansônica. Carcinoma hepatocelular.


 

 

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Recebido para publicação em 20/10/83.

 

 

* Supported by CNPq (Plano Institucional de Apoio à Pesquisa, Sub-Reitoria de Pesquisa e Pós-Graduação, UFES)