Carlos Eduardo Tosta
Bolsista do Conselho Nacional de Pesquisas
RESUMO
São apresentados os resultados preliminares de um estudo evolutivo da localização renal de complexos antígeno-anticorpo solúveis em ratos infectados com P. berghei. Embora no 2º dia o animal já apresentasse parasitos circulantes e no 6.° dia fôsse demonstrado anticorpos circulantes, somente no 12.° dia ficou caracterizada a presença simultânea de antígeno e anticorpo, por imunofluorescência, nos glomérulos e arteríolas renais, correspondendo a uma queda do nível sérico de complemento. No 16.° dia o depósito glomerular era mínimo e o complemento retornou a níveis considerados normais.
Após um confronto com os dados obtidos em outros trabalhos o A. sugere que o P. berghei possa apresentar uma ação patogênica para o hospedeiro através da formação de complexos Ag-Ac embora acentuando a necessidade de estudos adicionais.
SUMMARY
This report is the result of a preliminary study of the demonstration of antigen-antibody complexes in the kidney of albino rats infected with Plasmodium berghei. Although the presence of parasites in the peripheral blood was demonstrated on the 2nd day of infection and the circulating antibodies on the 6th day by the fluorescent antibody technique, it was only on the 12th day that there were found deposits of antigen and antibody in the glomeruli and on the internai elastic lamina associated with a decrease of the levei of the hemolytic complement in the serum. On the 16th day the glomeruli presented a minimum deposit and the complement reached normal leveis.
The author suggests that P. berghei can act as a pathogen to the host by means of formation of soluble antigen-antibody complexes. However, this subject needs additional study.
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* Trabalho da Clínica de Doenças Infectuosaí e Parasitárias da F.M. da U.F.R.J. e do Instituto Brasileiro de Tropicologia Médica, Cx. Postal 1859, Rio de Janejro.
