Humberto Menezes
Departamento de Patologia, Faculdade de Medicina de Ribeirão Prêto, S. Paulo, Brasil
ABSTRACT
“Vaccines” prepared from parasites of an avirulent cultivated Y strain of T. cruzi, suspended in phenolated 1/10.000 saline solution, with aluminum stearate, containing alive parasites, gave high degree of protection to mice against a posterior infection with virulent blood forms of the same parasites and strain.
The degree of protection with 1/1000 and 1/10.000 phenol “vaccines”, with no alive parasites, was very poor specially in the first group.
The immunity seems to be related to the number of alive trypanosomes in the “vaccines”.
RESUMO
Suspensões salinas fenoladas de Trypanosoma cruzi, cêpa Y, mantidas por 15 anos em meio de cultura artificial, desde que contenham alguns tripanosomas vivos, constituem bom meio de proteção, para camundongos, contra ulterior infecção com cêpa virulenta.
O fenol a 1/10.000 determina alterações da forma e da motilidade dos parasitas o que faz supor uma redução maior ainda de sua capacidade infectante.
O grau da imunidade parece relacionado com o número de parasitas vivos contidos nas “vacinas”.
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REFERENCES
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This work has been supported by a Grant from Pfizer Química Ltda. Brasil.
Presented partially before the meeting of the Sociedade de Biologia, Ribeirão Prêto, September 21, 1967.
