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Donor-derived Cryptococcus gattii complex infection after liver transplantation

Carneiro, Bruno Hassunuma Breda, Giovanni Luis Cognialli, Regielly Caroline Raimundo Santos, Germana Davila dos Vicente, Vania Aparecida Perondi, Eduardo Gnoatto França, João Cesar Beenke Queiroz-Telles, Flávio

DOI: 10.1590/0037-8682-0297-2024

Cryptococcal disease is the third most common invasive fungal infection in solid organ transplant recipients and is associated with high-morbidity and -mortality rates. Donor-derived Cryptococcus spp. infection typically manifests within the first month post-procedure and has historically been caused by C. neoformans complex, predominantly in kidney recipients, but also after liver transplantation. We report the first documented case of donor-derived, early-onset C. gattii complex meningoencephalitis following liver transplantation in a 54-year-old woman, successfully treated with amphotericin B and fluconazole, and review the relevant literature.

Keywords: Cryptococcosis; C. gattii; Solid organ transplant