Pedro Raso; Paulo Marcos Z. Coelho; Nivaldo H. Toppa; Rômulo T. Mello
ABSTRACT
In this study, which was undertaken in relation to the histopathologic behavior of two different strains (LE-Belo Horizonte, MG and SJ – São José dos Campos, SP) in infections and reinfections (homologous or heterologous) with Schistosoma mansoni, the authors confirmed a more accentuated pathogenicity of the SJ strain. All the reinfections showed the presence of typical granulomas of the acute phase, when performed either with the same strain (homologous) or with a different strain (heterologous) of the parasite of the primo infection. The possible mechanisms responsible for reactivation of the immunopathologic response in reinfections are discussed.
Keywords: Granuloma. Granulomatous reaction. Schistosoma mansoni. Geographical strains.
RESUMO
No presente estudo, verificou-se o comportamento histopatológico das infecções e reinfecções, homólogas ou heterólogas, das cepas LE (Belo Horizonte, MG) e SJ (São José dos Campos, SP) de Schistosoma mansoni. Confirmou-se uma maior patogenicidade da cepa SJ de S. mansoni. As reinfecções, independentemente de terem sido feitas com a mesma cepa (homóloga) ou cepa diferente da primo infecção (heteróloga) do parasito, mostraram a presença de granulomas típicos da fase aguda. São discutidos os possíveis mecanismos responsáveis pela reagudização da resposta imunopatológica nas reinfecções.
Palavras-chave: Granuloma. Reação granulomatosa. Schistosoma mansoni. Cepas geográficas.
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REFERENCES
1. Andrade ZA, Warren, KS. Mild prolonged schistosomiasis in mice: alteration in host response with time and the development of portal fibrosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 58:53-57, 1964. [ Links ]
2. Boros DL. Immunopathology of Schistosoma mansoni infection. Clinical Microbiology Reviews 2:250-269, 1989. [ Links ]
3. Boros DL, Warren KS. Delayed hypersensitivity granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs. Journal Experimental Medicine 132:488-507, 1970. [ Links ]
4. Coelho PMZ, Raso P, Mello RT, Toppa NH. Schistosoma mansoni: Diferenças entre cepas no hospedeiro vertebrado. In: I International Symposium on Schistosomiasis. Rio de Janeiro, RJ, p. 132, 1987. [ Links ]
5. Coelho PMZ, Raso P, Mello RT, Toppa NH. Dimensões do granuloma hepático produzido por ovos de duas cepas geográficas de Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz 84:213-217, 1989. [ Links ]
6. Coelho PMZ, Raso P, Mello RT, Toppa NH. Schistosoma mansoni in mice: Modulation of granulomatous response after reinfection and chemotherapeutic treatment. Revista da Sociedade Brasileira de Medicina Tropical 27:119-125, 1994. [ Links ]
7. Fiorentino DF, Zlotnik A, Mosmann JR, Howard O’Garra A. IL-10 Inhibits cytokine production by activated macrophages. Journal of Immunology 147:3815-3822, 1991. [ Links ]
8. Hang LM, Warren KS, Boros DL. Schistosoma mansoni: antigenic secretions and the etiology of egg granulomas in mice. Experimental Parasitology 35:288-298, 1974. [ Links ]
9. JunqueiraLCV, Bignolas G, BrentaniR. Picrosirino staining plus polarization microscopy, a specific method for collagen detection in tissues sections. Histochemical Journal 11:47-54, 1979. [ Links ]
10. Mosmann TR, Moore KW. The role of IL-10 in cross regulations of Thl e Th2 responses. Immunology Today 12:A49-A53, 1991. [ Links ]
11. Pearce EG, Caspar P, Grzych JM, Lewis FA, Sher A. Row regulations of Thl cytokine production accompanies induction o f Th2 responseby a parasitic helminth, Schistosoma mansoni. Journal of Experimental Medicine 173:159-166, 1991. [ Links ]
12. Phillips SM, Lammie PJ. Immunopathology of granuloma formation and fibrosis in schistosomiasis. Parasitology Today 2:296-302, 1986. [ Links ]
13. Scott P, Kaufmann SHE. The role of T cell subsets and cytokines in the regulation of infection. Immunology Today 12:346-348, 1991. [ Links ]
Adress to correspondence:
Prof. Paulo Marcos Z. Coelho.
GIDE/ICB/UFMG,
Caixa Postal 486,
30161-970
Belo Horizonte, MG, Brasil.
Recebido para publicação em 30/03/94.
Universidade Federal de Ouro Preto, Ouro Preto, MG e Departamentos de Parasitologia do Instituto de Ciências Biológicas, de Anatomia Patológica da Faculdade de Medicina e de Análises Clínicas e Toxicológicas da Faculdade de Farmácia, Universidade Federal de Minas Gerais, MG, Brasil.
Financial support from CNPq, FAPEMIG, FINEP, PRPq, Brazil and WHO, Switzerland.