Mércia Cardoso de Paiva; Aluízio Prata; Rômulo César Saboia Moura; Aymoré Vaz Pinto; Fernando Santos
RESUMO
Um caso de hepatite de Lábrea nos possibilitou um estudo do comportamento dos fatores da coagulação nessa doença. O objetivo principal foi estudar a coagulação do sangue, visando: 1. conhecer os níveis dos fatores da coagulação na Febre Negra; 2. contribuir para o melhor conhecimento da doença, principalmente no que se refere às manifestações de hemorragia; 3. tentar correlacionar a gravidade do quadro clínico e prognóstico à intensidade das alterações dos fatores da coagulação.
Os resultados evidenciaram uma alteração acentuada da crase sangüínea, sugerindo que, além do quadro infeccioso, o paciente desenvolveu, igualmente, uma síndrome de coagulação intravascular disseminada.
Palavras-chave: Plasmodium falciparum. Resistência in vitro. Cloroquina. Amodiaquina. Quinino. Mefloquina.
ABSTRACT
A case of Labrea’s hepatitis has allowed us to study the behavior of some coagulation factors in that disease. The main objectives were:
1. To measure the plasmatic concentration of the blood coagulation factors:
2. To further our understanding of that disease, including the hemorragic manifestations;
3. To correlate the severity of the clinical picture and prognosis with the intensity of change of the blood coagulation factors.
The results showed great alterations of blood coagulation, suggesting that besides the infectius picture the patient had also developed a disseminated intravascular coagulation syndrome.
Keywords: Hepatitis. Black fever. Coagulation. Disseminated intravascular coagulation.
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Endereço para correspondência:
Dra. Mércia Cardoso de Paiva
Faculdade de Ciências da Saúde
Universidade de Brasília
70910
Brasilia, DF, Brasil.
Recebido para publicação em 15/8/1983.
* Trabalho realizado na Faculdade de Medicina da Universidade de Brasília, com a ajuda financeira do CNPq.
