Zilton A. AndradeI; Sonia G. AndradeII
IProfessor Adjunto IIProfessor Assistente
RESUMO
São apresentados os dados clínico-patológicos de dois casos de entomoftorose nasal, nova doença humana causada por um ficomiceto – Entomophthora coronata. Os pacientes, uma menina e um homem, com 8 e 44 anos de idade respectivamente, apresentaram doença localizada, com nódulos no nariz e região paranasal, edema e deformação da face. O parasito foi isolado do primeiro caso, mas todas as tentativas para isolá-lo no segundo caso resultaram negativas. Histologicamente, havia reação granulomatosa, fibrose e edema, em torno de hifas não septadas, as quais exibiam envólucro eosinófilo amorfo em torno. Foram demonstrados anticorpos circulantes contra, as hifas do E. coronata no soro de um dos pacientes. O material eosinófilo em torno das hifas continha fibrina e material auto-fluorescente sob luz ultra-violeta, provavelmente lipofuscina, mas não foram demonstrados anticorpos ou antígenos nesta área.
A apresentação destes casos, os primeiros a serem descritos no Brasil, é acompanhado, de uma revisão geral do assunto, pois tal poderá vir a ser de interesse para aqueles que estudam os problemas da patologia tropical em nosso meio.
ABSTRACT
Two cases of rhino-entomophthora-mycosis, a new human disease caused by a phycomycete Entomophthora coronata, are presented. The patients, a girl and a man aged 8 an 44 years respectively, showed a localized disease involving the nose and paranasal areas. The parasite was easily isolated from the first patient but every attempt to cultivate the organisms from the second resulted unsuccessful. Histologically, there were granulomatous formations, fibrosis and edema, around nonseptated hyphae, which appeared surrounded by an amorphous eosinophylic material. Antibodies binding specifically to the hyphae were, demonstrated in one patient’s serum. The eosinophylic material around the hyphae contained fibrin and a yellowish autofluorescent component, probably hypofuscin, but neither antibodies, nor antigens could be demonstrated in it.
The presentation of the cases is followed by n. general review on rhino-entomophtroro-mycosis, since, that disease may be fo importance to doctors working in Brasil, a tropical country.
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Recebido para publicação em 13.8.72.
Trabalho cio Serviço de Anatomia Patológica, Hospital Prof. Edgard Santos, Faculdade de Medicina da Universidade Federal da Bahia.
